Research on Joint Model of Longitudinal Data Lead Investigator: Yazhou Wu Institution : Wake Health E-Mail : yawu@wakehealth.edu Proposal ID : 938 Proposal Description: Our research aim is to explore a new kind joint statistical modeling method to describe the complex relationship, concerning for the growth of whole and individual differences as time changing for multiple longitudinal data. Because, modeling and analysis of multiple longitudinal data with missing value in biomedical big data is the key and difficult topic in the study of statistical methodology, and traditional modeling and analysis methods have been unable to describe and characterize the complex relationship of variables. Through the analysis and application of the different data sets, confirm the reliability, validity and robustness of the joint statistical modeling for multiple longitudinal data using the new method, and we emphasis on discuss and set up the statistical analysis strategies of multiple longitudinal data based on the different response variable types, not negligible loss mechanism and different analysis purposes. Now, we are looking for a complex and big biomedical longitudinal data #65288with multiple time points of repeated measurement data#65289to verify the new statistical method. So, I want to request the whole the Uniform Data Set (UDS) and its all follow-up visit data to apply to my research. The main variables of interest include the baseline indicators, independent variable and dependent variable (response variables), latent variables for some cases.